Relationships among national and international institutions and religious organizations and communities color politics, governance expectations, and daily life in much of the world. The upheavals of the COVID-19 crisis have cast new light on perennial issues of ethics and belief fundamental for institutions and processes of governance. As we move into an unsettling post-COVID-19 era, global religious and interfaith networks aspire to revitalized roles in advancing global agendas. Many questions will arise along the path, including how religious ideals are framed and how contested questions—theological, philosophical, and practical—are to be addressed.